Auto-save render multilayer EXR

Hi people.

Do you know if there is a way to automatically save renders as multilayer EXR?
Maybe there is some limitations in the API?

Thanks

Open startup file.
Change render output format to desired format.
Save startup file.
Done.

what is that? lol

I’m saying that I’m trying to make a script that automatically saves multilayer EXR after I press f12.