During 2.80 development we tried some unusual or clever key combinations, and after user testing the conclusion was always that we had to revert it because of serious problems.
Personally I think we should not try to invent our own system for things like this, and stick to using the typical modifier keys in our default keymap and settings. It’s fighting the way operating systems are designed to interpret keys and what users are used to, I don’t think it’s worth it.